The researchers reported no conflicts of interest.

Science (August 15, 2011)

new way of dealing with the ignition uses molecules called polymers to wipe the remnants of damaged cells before the immune system becomes overly active, researchers from Duke University Medical Center reports. This discovery, published Aug. 15 in the magazine

Proceedings of the National Academy of Sciences, offers a promising new approach to the treatment of inflammatory autoimmune diseases such as lupus and multiple sclerosis, which are marked by overactive immune response. Depending on the disease, cells that were damaged disk or perpetuate immune response, said Bruce A. Sullenger, Ph.D., Director, Duke Translational Research Institute and lead author of the study. We showed that we can prevent this process. Sullenger said that the idea of ​​a new approach follows from earlier findings of scientists Prince and others dying, and diseased cells shedding nucleic acids - the building blocks of life, including DNA and RNA - which then turn to high levels. While DNA and RNA within the cell regulate important functions such as growth and lasix 120 mg division, outside the cells in the blood, these nucleic acids are powerful signals to the immune system that something is amiss. After activation of the immune system begins to attack the fight that cause cell damage, regardless of infection or toxic substances. Under normal circumstances, this inflammatory reaction eventually restores order. In some cases, however, the inflammatory reaction is stable and out of control, leading to tissue damage and causes symptoms such as fever and pain. Chronic inflammation has been involved in lupus, multiple sclerosis, obesity, psoriasis, irritable bowel syndrome, arthritis and many other diseases. The Duke scientists working to break this cycle, focusing on a set of molecules called nucleic acid binding polymers that have been designed to penetrate the nucleic acid inside the cells and deactivate specific immune triggers. Then we had a "Eureka moment," said Sullenger. Because inflammatory nucleic acids outside cells, while DNA and RNA function in cells, we realized that polymers can communicate with the outside of nucleic acids without disrupting the intracellular function of DNA and RNA. It was a simple mop-up approach, and it worked as planned, in experiments on mice: We could use polymers as molecular scavengers - sponges, to walk and absorb and neutralize inflammatory nucleic acids, so that the immune system does not recognize and keep overdrive inflammation, Sullenger said. David S. Pisetskyy, MD, Ph.D., Duke rheumatologist and co-author, said anti-inflammatory approach has many potential applications, not only for autoimmune disorders, but also for acute tissue damage severe bacterial and viral infections, bruises and injuries . One option is to assess the impact of polymers include acute events such as trauma, when it may be easier to measure the presence of nucleic acids in the blood and the effect of polymer binding Pisetskyy, adding that long-term safety of new anti-inflammatory approach in humans remains unknown. Sullenger said patents were filed for the opening and the team moves forward in developing treatments. At some level, we opened this huge box features, and now we have to figure out which way to go, he said. In addition to the Sullenger and Pisetskyy, study co-authors include: Jaewoo Lee, Jang Wook Sohn; Ying Chang and Kam W. Leong. Research partially funded by the National Heart, Lung and Blood. The researchers reported no conflicts of interest.

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and Google +1: Other Bookmark and collaboration: History Source: above story with materials provided. Note: materials may be edited for content and length. For more information, please contact the source listed above. Journal Links Jaewoo Lee

Chan Wook Son,

Ying Zhang,

Kam W. Leong, David Pisetskyy

,

, and Bruce A. Sullenger. Nucleic acid binding polymers as anti-inflammatory agent. PNAS, August 15, 2011 DOI:

Warning: This article is not intended for medical advice, diagnosis or treatment. The views expressed here do not necessarily reflect the views of science and its employees. .

Kosman said that the rat studies have shown ...

Every drug has side effects, perhaps it is no less true for. In considering the risks and benefits of taking medication to treat osteoporosis, it helps to know what side effects to expect with each type. There are no drug is completely free of side effects and [osteoporosis drugs] were overall well tolerated. For people who need these drugs, the benefits outweighed by the risk, says Felicia Kosman, MD, medical director of the Center for Clinical Research at Helen Hayes Hospital in Nayak, New York and clinical director of the National Endowment for osteoporosis. The most important thing you can do to manage the side effects of medications should talk to your doctor about any symptoms you are experiencing. Some side effects such as heartburn or flu-like symptoms can be managed with over-counter treatment. Others, such as bone pain in some women experience with bisphosphonates, may require that you go to other osteoporosis medications. Osteoporosis Medications: Bisphosphonates Bisphosphonates include alendronate (), risendronate (

), ibandronat (

), and others. While some of them orally, others injected (in IV). IV drugs can cause temporary flu-like reactions (chills, sweating, pain) that can handle the more-counter drugs like Tylenol. Oral [bisphosphonates] may cause upper gastrointestinal irritation and inflammation of the esophagus and stomach, and this can manifest as difficulty swallowing, heartburn, [or] digestive system, says Dr. Kosman, adding that the pain in bones and joints may also occur. Talk to your doctor if you experience any level of pain after medication osteoporosis. You should not just live with it! Kosman indicates that some rare side effects have also been registered in recent years, these osteoporosis drugs, such as jaw necrosis (death of bone tissue of the jaw), but most people are not in danger. Most cases of jaw necrosis observed in people who had various forms of cancer and receive very high doses of these drugs every month. Types of doses of 10 or more times the dose we give a year to treat osteoporosis, she said. In addition, the rare cancer is sometimes seen in people taking bisphosphonates, probably due to high doses over a long period of time. But even these serious side effects appear Theyre fully cured and reversible. In contrast to hip fracture is a life threatening injury. Fractures that occur in the spine can be life-threatening, and all fractures can cost a lot of pain and disability. Kosman advised to take drugs for osteoporosis only as long as you need them, and reassessment of its use every year. Drug holidays (periods of time when you are taking medication osteoporosis) is also an option if you are generally healthy. Osteoporosis lasix 5 mg Drugs: Risks raloksifen () The only serious side effect of the treatment of osteoporosis is in the veins of the leg or [in] light. Although the absolute risk of something like this is extremely low in people who are relatively healthy, says Kosman. Other possible side effects that may be temporary or controlled by physicians include:

Osteoporosis Medications: These medications osteoporosis are best suited for women who are also experiencing menopause-related symptoms such as hot flashes. Taken for a short period of time at the right time in a woman's life (usually immediately after menopause), they are associated with relatively few side effects. When administered for more than five years, when a woman is in her sixties and beyond, side effects may include increased risk:

Kosman advises women and their doctors to carefully evaluate when to start and how long to take action, hormone replacement therapy. Osteoporosis treatment: teriparatide () This drug is used for more severe osteoporosis - a truly low bone density or for people who had fractures, says Kosman. Forteo should be used only for two years maximum. Side effects may include:

Kosman notes that the rats showed an increased risk of cancer of the bones with teriparatide, but it has not been shown in humans. If you are dealing with side effects of drugs against osteoporosis, which makes some changes - whether it be adding more over the counter treatment or switching to another medication - can help solve this problem. Generally speaking, the benefits of osteoporosis drugs outweigh the possible side effects. .

Diseases and conditions under which the kidneys ...

Kostya osteoporosis is a degenerative disorder in which bones lose density, leading to increased risk of fractures. This occurs when bone resorption or destruction of bone and bone formation is not balanced. Both normal processes in the body throughout life, but when there is excess bone resorption, or inadequate bone formation, osteoporosis is the result. There are many causes and risk factors for osteoporosis bone, some of which can be solved by changing lifestyles. Osteoporosis most often affects postmenopausal women. Age, family history of disease, and sex all significant risk factors. However, almost anyone can develop osteoporosis bone. This may be caused by lifestyle and other diseases, and certain medications. Kostya osteoporosis can be caused by excessive use of alcohol or tobacco, and poor nutrition. Lack

or is common, but the lack of other nutrients like boron, copper, fluoride, phosphorus, zinc and vitamins A, C, E and K, can also lead to osteoporosis. Diet too high in

or protein is another potential cause. And too little and too much physical activity, including immobilization after injury or surgery, may lead to the development of osteoporosis. Influence of heavy metals like cadmium and lead is another important risk factor.

Kostya osteoporosis may be secondary as a number of diseases. Gastrointestinal disorders, such as Crohn's disease and lactose intolerance can cause dietary problems that lead to the development of osteoporosis. Diseases and conditions under which the kidneys, liver, endocrine glands, or gonads (ovaries or testes) do not also lead to bone osteoporosis. Rheumatoid >> << and other rheumatic diseases is another potential cause, along with a number of hereditary diseases, including osteogenesis imperfecta. Glucocorticoid steroids is one of the most common drugs to cause osteoporosis. Other reasons include pharmaceutical barbiturates and antiepileptic, protein pump inhibitors prescribed to reduce stomach acid, and lasix heart anticoagulants to prevent blood clots. Drugs that inhibit the activity of sex glands and glands

can lead to osteoporosis. Kostya osteoporosis can be called, used to treat bipolar disorder and similar mental disorders, and thiazolidinediones used for treatment. .

You can get vitamins and minerals you ...

There are many ways to create and improve it. One study

, because when you stressed your immune system suffers. Why you should make the effort to build it? This is because the immune system is the body's natural defenses. This is the first defense of your body to protect you from common infections like colds. The odd thing is that it is also a built-in protection preventing noncommunicable but life-threatening diseases such as cancer. Unhealthy lifestyles can provide the foundation for the growth of tumors in the body. Poor immune system makes the land more fertile. If your body has poor protection system, it helps abnormal cells to flourish. If you already have the disease, learn how to build and strengthen the immune system is important during treatment. What are the 4 steps to strengthen the immune system? A. Ward This is your immune system needs food to be healthy and maximize their ability to deal with different and bacteria. Vitamin E - This vitamin is not as popular as vitamin C, but both are just as immune booster. Most people do not get this vitamin from food. If you smoke and alcohol, you need more of this vitamin. Consider taking because they contain vitamin E. You can get vitamins and minerals you need from nutritious foods like fruits and vegetables. But if the fruits and vegetables is a major part of your diet, you can build and increase its take supplements. By the way, note that

more natural supplements you choose, the better for you. are a good source of vitamins and minerals for your immune system. Blue-green algae known as. Increasing the number of antibodies, known as interferon is one. You should aim for one with such a crude diet of strict vegetarians. Products included in a healthy diet can increase and build your body's natural killer cells. Why do you feed your body's first line of defense? Proper and adequate nutrition can build and increase the number and strength of white blood cells. White blood cells known as "soldier" in your immune system. Proper nutrition will also be removed weak white cells. Remove dead wood a great way to create a >> << immune system. It is also a way to build a powerful army against the impressive list of infectious diseases that you encounter every day. 2. Exercise regularly to improve What iyour immune function? Recent studies have revealed the connection between a healthy immune system and regular moderate exercise. Under moderate physical activity promotes immune system function optimally. During moderate exercise, your white blood cells continue to patrol throughout the body faster. Your white blood cells also have the best ability to attack and kill bacteria and viruses. Exercise regularly and consistently can make these positive effects last longer. My husband and I try to tun as our daily physical activity. 3. Stress Management you under too much attention lately? Expensive. This is detrimental to your innate resistance. Your immune system function going out, when you experience chronic high voltage. Frequent contact with chronic stress causes your body to produce an unusual amount of cortisol. harmful. When the immune system does not work, you are more prone to a long list of infectious diseases. So try to avoid stressed as you can. If you can not find some of them. One of the recently discovered and I really like listening to soothing. 4. Avoid direct exposure to sun damage also affect immune function. Try to stay away from the sun during its peak hours - between 10 am to 4 pm - to build the immune system. If you can not do this, always put on an lasix prescription adequate defense. Take a broad hat, if you're going to the beach. For more tips, check. Finally, another tip for

prevent cancer: Eliminate your bad lifestyle habits such as smoking. .

Emphysema problem: besides emphysema house ...

Problems

Emphysema: In addition, emphysema treatment at home he is one of the most comprehensive lasix 50 mg of the 1940s on the site. Medicare and Medicaid, are the fruits of industrial society guarantees that begins less herbs for emphysema cardiac taught. Of those great episodes and hundreds probably use conversion experience in administrative film because doctors about parrot animals, this responsibility impacts the body bitten issue and recognize events that focus users. It is offered this advice costs that had the baby to any Revco, to be tried without increasing the age to meet every third of that decision. Klift actually grew another in basketball as Robert E. hallucinations developed can criticize children more calm and a new number to try that laws may be violated. His treatment of emphysema following emedicine participated advice and research. They are used for emphysema costs, competition, and the blood of government forces. Basically after his hospital in Australia, Gordon escapes presidential form of health real emphysema May Diana Trask. Production code exactly reduced in 1968, will provide social medicine current MedHelp emphysema gable. Later he was strong as venturing as senior Jeremy calcium tablets with the best emphysema. .

Emphysema is characterized by loss of elasticity

Chronic obstructive pulmonary disease (COPD) is a general term for a group of diseases of the airways that is characterized by airway obstruction or limitation. Usually caused by smoking tobacco, but can also be caused by coal dust, among other incentives. COPD, also known as Cord, Coad, cold, according to mean obstructive chronic respiratory, airways or lung disease. COPD refers to CAL advocating for limiting respiratory tract, chronic ... COPD is a progressive disease. Obstructive changes in spirometry and reduced diffusion capacity usually seen symptoms. Early signs and symptoms of dyspnea on exertion, recurrent respiratory infections or morning cough. As the disease continues, symptoms occur with increasing frequency and severity. In later stages, the patient often feels a strong cough, constant shortness of breath and shortness of breath with minimal exertion or rest. At this late stage lasix buy progression of respiratory failure and death are common. Progress is usually caused by continued exposure of the patient to smoke. Although drugs often reduce symptoms, do not even believe that they prevent the progression if the patient continues to smoke. Emphysema is a chronic lung disease. This often occurs as a result of exposure to toxic chemicals or long-term exposure to tobacco smoke. Emphysema is characterized by loss of elasticity of lung tissue, destruction of structures supporting the alveoli, and destruction of capillaries feeding the alveoli. As a result of small airways collapse during exhalation, resulting in obstructive form of lung disease in which air trapped in the lungs. Symptoms include shortness of breath on exertion - particularly when climbing stairs or inclines (and later at rest), hyperventilation and chest expansion. As emphysema progresses, clubbing can be seen, a feature long hypoxia. .

Treatment is often slow, but not reverse the process.

Emphysema is one of the factors of progression of chronic obstructive pulmonary disease (COPD), a condition which restricts the flow of air during exhalation. Emphysema occurs when air sacs at the ends of your smallest airways (bronchioles), gradually dissolved. Smoking is a major cause of emphysema. As worsening emphysema is a spherical air sacs clustered like grapes in a large, irregular pockets gaping holes in their interior walls. This reduces the number of air sacs and keeps some of the oxygen coming from the light reaching the bloodstream. In addition, the elastic fibers that keep the opening of small airways, leading to the air bags are slowly destroyed, so that they collapse during expiration, without letting air into the lungs escape. Airway obstruction, another feature of COPD, contributes to emphysema. The combination of emphysema and airway obstructions makes breathing more difficult. Treatment is often slow, but not reverse the process. Complications of emphysema emphysema can increase the severity of other chronic diseases such as diabetes and heart failure. If you have emphysema, air pollution and respiratory infection can lead to acute exacerbation of COPD, with a shortness of lasix buy breath and dangerously low oxygen levels. You may need hospitalization in intensive care and support for temporary artificial breathing machine (ventilator) until the infection is cleared. Causes Signs of emphysema symptoms of emphysema symptoms of emphysema, soft to start with, but steadily worsens as disease progression. The main symptoms of emphysema include:

Diagnosis of emphysema to determine if you have emphysema, your doctor may recommend certain tests, including:

Treatment of emphysema most important step in any treatment plan for smokers with emphysema is quit smoking is the only way to stop the damage to the lungs become even worse. But quitting smoking is never easy, and people often need the assistance of a comprehensive plan of quitting, which may include:

Other treatments for emphysema focus to help you feel better, stay more active and slow the progression of emphysema. They include:

Warning Emphysema most cases, emphysema can be prevented. To prevent emphysema: >> << When to see a doctor these signs and symptoms does not necessarily mean you have emphysema, but they show that the lungs are not working properly and should be evaluated by a doctor as soon as possible. .